Article

Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture

2025-07-30

Abstract excerpt

Human midbrain organoids (hMOs) derived from induced pluripotent stem cells provide a powerful system to model disorders involving dopamine (DA) dysfunction, including Parkinson’s disease (PD) and neuropsychiatric conditions. However, current differentiation protocols still fall short in recapitulating early specification, substantia nigra pars compacta (SNpc)-like identity, and the functional maturation of vulner...

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Literature Corpus work: 762b6292-91ba-5a76-97e6-d600f719b555
DOI: 10.1101/2025.07.29.667404

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