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Article

Space exploration and risk of Parkinson’s disease: a perspective review

3 Jan 2025

Abstract excerpt

Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson's disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are...

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PMID: 39753605
DOI: 10.1038/s41526-024-00457-6

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