Article

Live cell kinetic analysis of the LMO2/LDB1 leukemogenic protein complex reveals a hierarchy of turnover with implications for complex assembly

2019-07-21

Abstract excerpt

<h4>Summary</h4> Multisubunit protein complexes operate in many cellular functions. The LDB1/LMO2 macromolecular complex has been posited to be critical in hematopoietic stem and progenitor cell specification and in the development of acute leukemia. This complex is comprised of core subunits of LMO2 and LDB1 as well as bHLH and GATA transcription factors. We analyzed the steady state abundance and kinetic stabil...

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Literature Corpus work: ba011bfa-af38-58e6-ab85-1ea280245f5c
DOI: 10.1101/706259

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