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Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma

20 Apr 2012

Abstract excerpt

LMO2 regulates gene expression by facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the germinal center (GC) and is expressed in GC-derived non-Hodgkin lymphomas. LMO2 is one of the most powerful prognostic indicators in diffuse large B-cell (DLBCL) patients. However, its function in GC B cells and DLBCL is currently unknown. In this study, we...

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PMID: 22517897
DOI: 10.1182/blood-2012-01-403154

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