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Article

LMO2 at 25 years: a paradigm of chromosomal translocation proteins

1 Jun 2015

Abstract excerpt

LMO2 was first discovered through proximity to frequently occurring chromosomal translocations in T cell acute lymphoblastic leukaemia (T-ALL). Subsequent studies on its role in tumours and in normal settings have highlighted LMO2 as an archetypical chromosomal translocation oncogene, activated by association with antigen receptor gene loci and a paradigm for translocation gene activation in T-ALL. The normal...

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PMID: 26108219
DOI: 10.1098/rsob.150062

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