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Article

Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.

Cell reports - 11 Jul 2013

El Omari Kamel, Hoosdally Sarah J, Tuladhar Kapil, Karia Dimple, Hall-Ponselé Elisa, Platonova Olga, Vyas Paresh, Patient Roger, Porcher Catherine, Mancini Erika J

Abstract excerpt

Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details of how these complexes form are poorly understood. One such complex, which contains the basic-helix-loop-helix heterodimer SCL:E47 and bridging proteins LMO2:LDB1, critically regulates hematopoiesis and induces T cell leukemia. Here, we report the crystal structure of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23831025
DOI: 10.1016/j.celrep.2013.06.008
PMCID: PMC3714592

Genes

LMO2
LDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.PMID 23831025Read ↗

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