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Article

The LMO2 oncogene regulates DNA replication in hematopoietic cells

13 Jan 2016

Abstract excerpt

Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL). Whether or not these oncoproteins interfere with other DNA-dependent processes is largely unexplored. Here, we show that LMO2 is recruited to DNA...

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PMID: 26764384
DOI: 10.1073/pnas.1515071113

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