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LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia

31 Mar 2020

Abstract excerpt

The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem and progenitor cell specification and in the development of acute leukemia. This complex is comprised of core subunits of LMO2 and LDB1 as well as single-stranded DNA-binding protein (SSBP) cofactors and DNA-binding basic helix-loop-helix (bHLH) and GATA transcription factors. We analyzed the steady-state abundance and kinetic stability of...

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PMID: 32229578
DOI: 10.1128/mcb.00652-19

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