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Article

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.

Molecular and cellular biology - 1 Feb 2016

Layer Justin H, Alford Catherine E, McDonald W Hayes, Davé Utpal P

Abstract excerpt

LMO2 is a component of multisubunit DNA-binding transcription factor complexes that regulate gene expression in hematopoietic stem and progenitor cell development. Enforced expression of LMO2 causes leukemia by inducing hematopoietic stem cell-like features in T-cell progenitor cells, but the biochemical mechanisms of LMO2 function have not been fully elucidated. In this study, we systematically dissected the...

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Share to Adaptor Proteins, Signal Transducing
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Share to Leukemia, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LIM Domain Proteins

Share to Protein Interaction Domains and Motifs

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Source

Open in PubMed Open full text

Identifiers

PMID: 26598604
DOI: 10.1128/MCB.00901-15
PMCID: PMC4719424

Genes

LMO2
LDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.PMID 26598604Read ↗

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