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Article

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.

Scientific reports - 10 Jan 2014

Sewell H, Tanaka T, El Omari K, Mancini E J, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts T H

Abstract excerpt

LMO2 was discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for haematopoiesis. LMO2 is made up of two LIM only domains (thus it is a LIM-only protein) and forms a bridge in a multi-protein complex. We have studied the mechanism of formation of this complex using a single domain antibody fragment that inhibits LMO2 by sequestering it in a non-functional form. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24407558
DOI: 10.1038/srep03643
PMCID: PMC3887373

Genes

LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.PMID 24407558Read ↗

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