Article

Context-aware sequence-to-function model of human gene regulation

2025-06-25

Abstract excerpt

Sequence-to-function models have been very successful in predicting gene expression, chromatin accessibility, and epigenetic marks from DNA sequences alone. However, current state-of-the-art models have a fundamental limitation: they cannot extrapolate beyond the cell types and conditions included in their training dataset. Here, we introduce a new approach that is designed to overcome this limitation: Corgi, a ne...

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Literature Corpus work: 2ed5a13d-c46c-5ad4-8bfa-dea0b6b4a351
DOI: 10.1101/2025.06.25.661447

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