Article

Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers

2022-09-17

Abstract excerpt

<h4>Background</h4> The largest sequence-based models of transcription control to date have been obtained by predicting genome-wide gene regulatory assays across the human genome. This setting is fundamentally correlative, as those models are exposed during training solely to the sequence variation between human genes that arose through evolution, questioning the extent to which those models capture genuine causa...

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Literature Corpus work: a754eab5-28fc-555c-82df-b29e2f0b4cab
DOI: 10.1101/2022.09.15.508087

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