Article

Learning interpretable representation for context-specific transcription regulatory networks using a foundation model

2025-04-03

Abstract excerpt

Gene expression is shaped by transcription regulatory networks (TRNs), where transcription regulators interact within regulatory elements in a context-specific manner. Despite significant efforts, understanding the intricate interactions of transcription regulators across different genomic regions and cell types remains a major challenge, largely due to data sparsity. Here, we introduce ChromBERT, a foundation mod...

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Literature Corpus work: bae5a496-3983-5fca-b70b-68f406c54ec3
DOI: 10.1101/2025.03.29.646077

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