Article

CREP: Cis-Regulatory Element Predictor Based on Fine-Tuned Enformer

2026-06-07

Abstract excerpt

A substantial fraction of disease-associated genetic variants reside in non-coding regions of the genome, where they act by perturbing cis -regulatory elements (CREs) such as enhancers, promoters, and insulators. While recent sequence-based deep learning models, such as Enformer, accurately predict continuous epigenomic signals from DNA sequence, they do not directly provide discrete and interpretable CRE annotat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56842bbe-1f30-5765-94f6-e89cafa87ff0
DOI: 10.64898/2026.06.05.730309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CREP: Cis-Regulatory Element Predictor Based on Fine-Tuned EnformerDOI 10.64898/2026.06.05.730309Read

CREATE: cell-type-specific cis-regulatory elements identification via discrete embeddingSemantic proximity Read

Effective gene expression prediction from sequence by integrating long-range interactionsSemantic proximity Read

Predicting cell type-specific epigenomic profiles accounting for distal genetic effects.Semantic proximity Read

Mapping enhancer-gene regulatory interactions from single-cell dataSemantic proximity Read

A sequence-based global map of regulatory activity for deciphering human geneticsSemantic proximity Read

Current genomic deep learning models display decreased performance in cell type specific accessible regionsSemantic proximity Read

An encyclopedia of enhancer-gene regulatory interactions in the human genomeSemantic proximity Read

RegFM: an interpretable context-aware foundation model for human transcriptional regulationSemantic proximity Read

Genome-Wide Prediction of <i>cis</i> -Regulatory Regions Using Supervised Deep Learning MethodsSemantic proximity Read

REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sitesSemantic proximity Read

CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq dataSemantic proximity Read

EnhancerTracker: Comparing cell-type-specific enhancer activity of DNA sequence triplets via an ensemble of deep convolutional neural networksSemantic proximity Read