Article

Functional Annotation of the Major Histocompatibility Complex Locus

2026-02-03

Abstract excerpt

The human major histocompatibility complex (MHC) locus has the greatest density of disease-associations in the human genome, including links to over 100 polygenic disorders. Its complex haplotype structure, rich gene density, and high degree of linkage disequilibrium combine to make deciphering the gene regulatory logic of the MHC locus extremely challenging. Employing complementary high-throughput CRISPR interfer...

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Literature Corpus work: b9fa515b-e467-53a6-8886-dc32d36b24cc
DOI: 10.64898/2026.02.01.703124

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