Article

Novel transcriptional activity and extensive allelic imbalance in the human MHC region

2017-09-10

Abstract excerpt

The major histocompatibility complex (MHC) region encodes human leukocyte antigen (HLA) genes and is the most complex region in the human genome. The extensive polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel tra...

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Literature Corpus work: 8906c723-889e-5ead-b398-f8e0a093c05c
DOI: 10.1101/186809

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