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Article

A super enhancer controls expression and chromatin architecture within the MHC class II locus.

The Journal of experimental medicine - 3 Feb 2020

Majumder Parimal, Lee Joshua T, Rahmberg Andrew R, Kumar Gaurav, Mi Tian, Scharer Christopher D, Boss Jeremy M

Abstract excerpt

Super enhancers (SEs) play critical roles in cell type-specific gene regulation. The mechanisms by which such elements work are largely unknown. Two SEs termed DR/DQ-SE and XL9-SE are situated within the human MHC class II locus between the HLA-DRB1 and HLA-DQA1 genes and are highly enriched for disease-causing SNPs. To test the function of these elements, we used CRISPR/Cas9 to generate a series of mutants that...

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Identifiers

PMID: 31753848
DOI: 10.1084/jem.20190668
PMCID: PMC7041702

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