Article

EXTENDED TUDOR-DOMAINS of the piRNA BIOGENESIS PATHWAY HAVE RNA-SPECIFIC NUCLEASE ACTIVITY

2021-10-25

Abstract excerpt

<h4>ABSTRACT</h4> piRNAs are essential for transposon repression and protecting the germline from deleterious mutations. piRNA biogenesis comprises a primary and secondary pathway, and involves PIWI clade argonaute proteins and ancillary factors. Secondary piRNA biogenesis is tightly coupled to transposon repression. It requires processing of the 3’ end of pre-piRNA during an amplification loop by an as yet unide...

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Literature Corpus work: b9e2a15b-61d9-5873-baf1-cbfe5ae185de
DOI: 10.1101/2021.10.25.465661

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