Article
A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
The EMBO journal - 23 Aug 2011
Handler Dominik, Olivieri Daniel, Novatchkova Maria, Gruber Franz Sebastian, Meixner Katharina, Mechtler Karl, Stark Alexander, Sachidanandam Ravi, Brennecke Julius
Abstract excerpt
PIWI proteins and their bound PIWI-interacting RNAs (piRNAs) form the core of a gonad-specific small RNA silencing pathway that protects the animal genome against the deleterious activity of transposable elements. Recent studies linked the piRNA pathway to TUDOR biology as TUDOR domains of various proteins bind symmetrically methylated Arginine residues in PIWI proteins. We systematically analysed the Drosophila...
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