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Article

Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila.

Development (Cambridge, England) - 1 Feb 2016

Wang Hui, Ma Zaijun, Niu Kongyan, Xiao Yi, Wu Xiaofen, Pan Chenyu, Zhao Yun, Wang Kai, Zhang Yaoyang, Liu Nan

Abstract excerpt

In eukaryotes, aberrant expression of transposable elements (TEs) is detrimental to the host genome. Piwi-interacting RNAs (piRNAs) of ∼23 to 30 nucleotides bound to PIWI clade Argonaute proteins silence transposons in a manner that is strictly dependent on their sequence complementarity. Hence, a key goal in understanding piRNA pathways is to determine mechanisms that modulate piRNA sequences. Here, we identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26718004
DOI: 10.1242/dev.128116
PMCID: PMC4760310

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