Article

Independent Generation of Amyloid-β via Novel <i>APP</i> Transcripts

2025-05-14

Abstract excerpt

The amyloid precursor protein ( APP ) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimer’s disease (AD). Aβ is produced through an initial β-secretase cleavage of APP, generating a 99-amino acid C-terminal fragment (APP-C99). Subsequent cleavage of APP-C99 by γ-secretase produces Aβ peptides of varying l...

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Literature Corpus work: c484edbd-e1af-5e51-8be6-e684630ec3fe
DOI: 10.1101/2025.05.13.651054

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