Article

Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42

2024-09-09

Abstract excerpt

<title>Abstract</title> <p>Genetic engineering of microglial cells is a promising therapeutic avenue emerging with advancements in gene delivery techniques. Using a recently developed AAV capsid for efficient in vitro transduction we report the engineering of microglia with CARs (CAR-Mic) targeting phagocytosis of amyloid beta 1‒42 (Aβ42). Functional screening of seven CAR constructs in human iPSC-derived microgl...

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Literature Corpus work: b9d631d7-6db2-5fb8-b81c-f4e6edfd2a78
DOI: 10.21203/rs.3.rs-4761741/v1

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