Article

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

2024-09-27

Abstract excerpt

Microglia are critical innate immune cells of the brain. In vivo targeting of microglia using gene-delivery systems is crucial for studying brain physiology and developing gene therapies for neurodegenerative diseases and other brain disorders such as NeuroAIDS. Historically, microglia have been extremely resistant to transduction by viral vectors, including adeno-associated virus (AAV) vectors. Recently, there h...

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Literature Corpus work: 0be74366-2776-5543-8b08-ca1d79bba739
DOI: 10.1101/2024.09.25.614546

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