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Microglia-specific targeting by novel capsid-modified AAV6 vectors

1 Jan 2016

Abstract excerpt

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids with microglia-specific transduction properties, we initially screened the most commonly used serotypes, AAV1-9 and...

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PMID: 27308302
DOI: 10.1038/mtm.2016.26

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