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Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges

31 May 2019

Abstract excerpt

Microglia have emerged as a critical component of neurodegenerative diseases. Genetic manipulation of microglia can elucidate their functional impact in disease. In neuroscience, recombinant viruses such as lentiviruses and adeno-associated viruses (AAVs) have been successfully used to target various cell types in the brain, although effective transduction of microglia is rare. In this review, we provide a short...

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PMID: 31158432
DOI: 10.1016/j.neulet.2019.134310

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