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Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency <i>in vitro</i> but has limited impact <i>in vivo</i>

2026-08-05

Abstract excerpt

Microglia play key roles in brain development, homeostasis, and neurodegeneration. Although multiple strategies for viral gene delivery to microglia have been reported, they have not been directly compared. Here, we developed microglia-targeting AAV capsids and benchmarked them against existing approaches. The novel capsids exhibit improved transduction efficiency in cultured mouse and human microglia, as well as...

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Literature Corpus work
265a74a5-3e11-5709-b5d6-df9d4d7892f8
DOI
10.64898/2026.08.05.739854
Open publication

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Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency <i>in vitro</i> but has limited impact <i>in vivo</i>DOI 10.64898/2026.08.05.739854
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