Article

Rewiring DNA Repair Activity into CRISPR Signal Transduction via Synthetic DNA Transducers

2025-07-11

Abstract excerpt

Harnessing the precision of CRISPR systems for diagnostics has transformed nucleic acid detection. However, the integration of upstream cellular signals into CRISPR-based circuits remains largely underexplored. Here, we introduce a synthetic transduction platform that directly links endogenous DNA repair activity to CRISPR-Cas12a activation. By coupling base excision repair (BER) events to a programmable DNA-based...

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Literature Corpus work: b9b97dfd-e4e4-5dee-a388-72957038437c
DOI: 10.1101/2025.07.11.664310

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