Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.

doi:10.1039/d6ay01060a

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Article

Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.

Analytical methods : advancing methods and applications - 20 Aug 2026

Wen Zonghua, Wei Cong, Shen Meng, Yu Songcheng

Abstract excerpt

Early detection of both genetic mutations and epigenetic modifications is critical for cancer diagnosis, but current methods often require separate assays or suffer from bisulfite-induced DNA damage. Here, we present a controllable CRISPR/Cas12a-based signal logic gate that enables simultaneous d...

Topics

DNA Methylation
Humans
Septins
CRISPR-Cas Systems
Mutation
Proto-Oncogene Proteins p21(ras)
Promoter Regions, Genetic
Colorectal Neoplasms
DNA Mutational Analysis

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