Article

Mitochondrial genomic alterations in cholangiocarcinoma cell lines

2024-09-11

Abstract excerpt

Cholangiocarcinoma (CCA) is a diverse collection of malignant tumors that originate in the bile ducts. Mitochondria, the energy converters in eukaryotic cells, contain circular mitochondrial DNA (mtDNA) which has a greater mutation rate than nuclear DNA. Heteroplasmic variations in mtDNA may suggest an increased risk of cancer-related mortality, serving as a potential prognostic marker. In this study, we investiga...

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Literature Corpus work: b9a9f223-e833-56b9-a9c1-5f794dfb3ada
DOI: 10.1101/2024.09.09.611963

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