Article
Novel mutations in cholangiocarcinoma with low frequencies revealed by whole mitochondrial genome sequencing.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Muisuk Kanha, Silsirivanit Atit, Imtawil Kanokwan, Bunthot Suphawadee, Pukhem Ake, Pairojkul Chawalit, Wongkham Sopit, Wongkham Chaisiri
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) mutations have been shown to be associated with cancer. This study explored whether mtDNA mutations enhance cholangiocarcinoma (CCA) development in individuals. MATERIALS AND METHODS: The whole mitochondrial genome sequences of 25 CCA patient tissues were determined and compared to those of white blood cells from the corresponding individuals and 12 healthy controls. The...
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