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Article

Mitochondrial genomic alterations in cholangiocarcinoma cell lines.

PloS one - 1 Jan 2025

Faipan Athitaya, Sitthirak Sirinya, Wangwiwatsin Arporn, Namwat Nisana, Klanrit Poramate, Titapun Attapol, Jareanrat Apiwat, Thanasukarn Vasin, Khuntikeo Natcha, Boulter Luke, Dokduang Hasaya, Loilome Watcharin

Abstract excerpt

Cholangiocarcinoma (CCA) is a diverse collection of malignant tumors that originate in the bile ducts. Mitochondria, the energy converters in eukaryotic cells, contain circular mitochondrial DNA (mtDNA) which has a greater mutation rate than nuclear DNA. Heteroplasmic variations in mtDNA may suggest an increased risk of cancer-related mortality, serving as a potential prognostic marker. In this study, we...

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Topics

Humans
Cholangiocarcinoma
Cell Line, Tumor
Genome, Mitochondrial
Bile Duct Neoplasms
DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Mitochondria

Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 40489465
DOI: 10.1371/journal.pone.0323844
PMCID: PMC12148147

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