Article
Identification of whole-genome mutations and structural variations of bile cell-free DNA in cholangiocarcinoma.
Genomics - 1 Sept 2024
Yin Lei, Duan Anqi, Zhang Wei, Li Bin, Zhao Teng, Xu Xiaoya, Yang Lixue, Nian Baoning, Lu Kai, Chen Sheng, Li Zhikuan, Liu Jian, Duan Qiaonan, Liu Dongyu, Chen Hao, Cui Longjiu, Chang Yanxin, Kuang Yue, Zhang Dadong, Wang Xiang, Zhang Yongjie
Abstract excerpt
Bile cell-free DNA (cfDNA) has been reported as a promising liquid biopsy tool for cholangiocarcinoma (CCA), however, the whole-genome mutation landscape and structural variants (SVs) of bile cfDNA remains unknown. Here we performed whole-genome sequencing on bile cfDNA and analyzed the correlation between mutation characteristics of bile cfDNA and clinical prognosis. TP53 and KRAS were the most frequently...
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