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Article

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies.

Oncotarget - 20 Jun 2015

Brandi Giovanni, Farioli Andrea, Astolfi Annalisa, Biasco Guido, Tavolari Simona

Abstract excerpt

Cholangiocarcinoma (CC) encompasses a group of related but distinct malignancies whose lack of a stereotyped genetic signature makes challenging the identification of genomic landscape and the development of effective targeted therapies. Accumulated evidences strongly suggest that the remarkable genetic heterogeneity of CC may be the result of a complex interplay among different causative factors, some shared by...

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Identifiers

PMID: 26142706
DOI: 10.18632/oncotarget.4539
PMCID: PMC4558112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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