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Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies.

BMJ evidence-based medicine - 23 Jul 2024

Bian Zilong, Wang Lijuan, Fan Rong, Sun Jing, Yu Lili, Xu Meihong, Timmers Paul R H J, Shen Xia, Wilson James F, Theodoratou Evropi, Wu Xifeng, Li Xue

Abstract excerpt

OBJECTIVE: To investigate the associations across genetic and lifestyle factors with lifespan. DESIGN: A longitudinal cohort study. SETTING: UK Biobank. PARTICIPANTS: 353 742 adults of European ancestry, who were recruited from 2006 to 2010 and were followed up until 2021. EXPOSURES: A polygenic risk score for lifespan with long (<lowest quintile), intermediate (quintiles 2 to 4), and short (>highest quintile)...

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PMID: 38684374
DOI: 10.1136/bmjebm-2023-112583

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