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Article

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan.

Nature medicine - 1 Apr 2020

Sakaue Saori, Kanai Masahiro, Karjalainen Juha, Akiyama Masato, Kurki Mitja, Matoba Nana, Takahashi Atsushi, Hirata Makoto, Kubo Michiaki, Matsuda Koichi, Murakami Yoshinori, Daly Mark J, Kamatani Yoichiro, Okada Yukinori

Abstract excerpt

While polygenic risk scores (PRSs) are poised to be translated into clinical practice through prediction of inborn health risks1, a strategy to utilize genetics to prioritize modifiable risk factors driving heath outcome is warranted2. To this end, we investigated the association of the genetic susceptibility to complex traits with human lifespan in collaboration with three worldwide biobanks (ntotal = 675,898;...

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PMID: 32251405
DOI: 10.1038/s41591-020-0785-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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