Article

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer’s disease comes from molecular studies in rodent models. However, these models may not fully recapitulate human disease as human and rodent astrocytes differ considerably in morphology, functionality, and gene expression. <h4>Methods</h4> To add...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df93d9b2-4b0d-5ec4-9e90-a7759d745bb7
DOI: 10.1101/2020.11.19.389023

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaquesDOI 10.1101/2020.11.19.389023Read

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β PlaquesSemantic proximity Read

Divergent Effects of <i>APOE3</i> and <i>APOE4</i> Human Astrocytes on Key Alzheimer’s Disease Hallmarks in Chimeric MiceSemantic proximity Read

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discoverySemantic proximity Read

Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial InteractionsSemantic proximity Read

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s DiseaseSemantic proximity Read

Glial and Neuronal Alzheimer's Disease-Related Alterations Reproduced in Human Induced Pluripotent Stem Cells With Presenilin-1 MutationSemantic proximity Read

Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the DishSemantic proximity Read

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse BrainSemantic proximity Read

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease StudiesSemantic proximity Read

Defined human tri-lineage brain microtissuesSemantic proximity Read

Vascularized Brain Assembloids with Enhanced Cellular Complexity Provide Insights into The Cellular Deficits of TauopathySemantic proximity Read

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?Semantic proximity Read