Article

Faster growth with shorter antigens explains a VSG hierarchy during African trypanosome infections: a feint attack by parasites

2017-04-26

Abstract excerpt

The parasitic African trypanosome, Trypanosoma brucei , evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs). The VSGs that periodically come to dominate in vivo display a hierarchy, but how this hierarchy arises is not well-understood. Combining publicly available genetic data with mathematical modelling, we repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b98c78f9-f3c8-51d1-8c67-027cd65dd79b
DOI: 10.1101/131029

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Faster growth with shorter antigens explains a VSG hierarchy during African trypanosome infections: a feint attack by parasitesDOI 10.1101/131029Read

A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.Semantic proximity Read

Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variationSemantic proximity Read

Emerging challenges in understanding trypanosome antigenic variationSemantic proximity Read

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infectionsSemantic proximity Read

Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.Semantic proximity Read

Commentary Antigenic variation in Trypanosoma brucei infections: an holistic viewSemantic proximity Read

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity.Semantic proximity Read

VSGs expressed during natural <i>T. b. gambiense</i> infection exhibit extensive sequence divergence and a subspecies-specific expression biasSemantic proximity Read

VSG switching in Trypanosoma brucei: antigenic variation analysed using RNAi in the absence of immune selection.Semantic proximity Read

African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune systemSemantic proximity Read

Variant surface glycoprotein diversity in African trypanosomesSemantic proximity Read

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat.Semantic proximity Read