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Emerging challenges in understanding trypanosome antigenic variation

22 Dec 2017

Abstract excerpt

Many pathogens evade host immunity by periodically changing the proteins they express on their surface — a phenomenon termed antigenic variation. An extreme form of antigenic variation, based around switching the composition of a variant surface glycoprotein (VSG) coat, is exhibited by the African trypanosome Trypanosoma brucei, which causes human disease. The molecular details of VSG switching in T. brucei have...

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PMID: 30271884
DOI: 10.1042/etls20170104

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