Article

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections

2026-07-31

Abstract excerpt

Trypanosoma brucei exploits an extreme form of antigenic variation to escape the mammalian immune response. This involves the progressive expression of antigenically distinct variant surface glycoproteins (VSGs) on the surface of individual parasites in the population, generating waves of parasitaemia that are successively cleared by host antibodies. Current paradigms were established using in vitro studies and ac...

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Literature Corpus work: 458ce160-e8e2-5ca3-bef6-82d10b47b7f9
DOI: 10.64898/2026.07.31.741217

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