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VSGs expressed during natural <i>T. b. gambiense</i> infection exhibit extensive sequence divergence and a subspecies-specific expression bias

2021-09-09

Abstract excerpt

Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa. The extracellular parasite evades antibody recognition within the host bloodstream by altering its Variant Surface Glycoprotein (VSG) coat through a process of antigenic variation. The serological tests which are widely used to screen for HAT use VSG as one...

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Literature Corpus work
a4dbcf55-c3e6-5ab6-b374-b6d043694d00
DOI
10.1101/2021.09.09.459620
Open publication

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