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Article

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat.

Nature microbiology - 1 Aug 2018

Pinger Jason, Nešić Dragana, Ali Liaqat, Aresta-Branco Francisco, Lilic Mirjana, Chowdhury Shanin, Kim Hee-Sook, Verdi Joseph, Raper Jayne, Ferguson Michael A J, Papavasiliou F Nina, Stebbins C Erec

Abstract excerpt

The African trypanosome Trypanosoma brucei spp. is a paradigm for antigenic variation, the orchestrated alteration of cell surface molecules to evade host immunity. The parasite elicits robust antibody-mediated immune responses to its variant surface glycoprotein (VSG) coat, but evades immune clearance by repeatedly accessing a large genetic VSG repertoire and 'switching' to antigenically distinct VSGs. This...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29988048
DOI: 10.1038/s41564-018-0187-6
PMCID: PMC6108419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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