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Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

4 Oct 2017

Abstract excerpt

Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamics of VSG coat replacement at the protein level, and the impact of this process on successful...

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PMID: 29018220
DOI: 10.1038/s41467-017-00959-w

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