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Article

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity.

Cellular microbiology - 1 Dec 2009

Morrison Liam J, Marcello Lucio, McCulloch Richard

Abstract excerpt

Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive archive of silent VSG genes to change the identity of the single VSG expressed at a time. VSG switching is driven primarily by recombination reactions that move...

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Identifiers

PMID: 19751359
DOI: 10.1111/j.1462-5822.2009.01383.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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