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Article

VSG switching in Trypanosoma brucei: antigenic variation analysed using RNAi in the absence of immune selection.

Molecular microbiology - 1 Sept 2005

Aitcheson Niall, Talbot Suzanne, Shapiro Jesse, Hughes Katie, Adkin Carl, Butt Thomas, Sheader Karen, Rudenko Gloria

Abstract excerpt

Trypanosoma brucei relies on antigenic variation of its variant surface glycoprotein (VSG) coat for survival. We show that VSG switching can be efficiently studied in vitro using VSG RNAi in place of an immune system to select for switch variants. Contrary to models predicting an instant switch after inhibition of VSG synthesis, switching was not induced by VSG RNAi and occurred at a rate of 10(-4) per division....

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Identifiers

PMID: 16135228
DOI: 10.1111/j.1365-2958.2005.04795.x
PMCID: PMC1618954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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