Article

Single-Molecule Proteomics via a Dynamic Translocase and Physics-Informed Machine Learning

2026-08-20

Abstract excerpt

Single-molecule protein sequencing promises to democratize clinical proteomics, but platforms retrofitting static DNA-sequencing nanopores face a fundamental biophysical bottleneck: they only measure one-dimensional excluded volume. Consequently, these static calipers struggle to resolve isobaric residues, requiring complex DNA-handle chemistries and target concentrations that exceed clinically relevant abundance...

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Identifiers and source

Literature Corpus work: 0c95bfa5-787d-51ba-af45-c2571498d215
DOI: 10.64898/2026.08.17.745284

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