Article

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines

2026-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous amino acids have transformed small-molecule discovery pipelines, but their application remains mostly limited to sites where reactive cysteines and lysines are present. Here we report a ninhydrin-bas...

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Literature Corpus work: 8d4748a1-e8f6-5ee1-a04c-ca98e5ba75b5
DOI: 10.64898/2026.01.05.697388

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