Article
Citrullination of Proteins: A Common Post-Translational Modification Pathway Induced by Different Nanoparticles<i>In Vitro</i>and<i>In Vivo</i>
25 May 2012
Abstract excerpt
AIM: Rapidly expanding manufacture and use of nanomaterials emphasize the requirements for thorough assessment of health outcomes associated with novel applications. Post-translational protein modifications catalyzed by Ca(2+)-dependent peptidylargininedeiminases have been shown to trigger immune responses including autoantibody generation, a hallmark of immune complexes deposition in rheumatoid arthritis....
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