Article

MspA Porin as a Local Nanopore Probe for Membrane-bound Proteins

2021-10-15

Abstract excerpt

Nanopore sensing is based on detection and analysis of nanopore transient conductance changes induced by analyte capture. We have recently shown that α-Synuclein (αSyn), an intrinsically disordered, membrane-active, neuronal protein implicated in Parkinson disease, can be reversibly captured by the VDAC nanopore. The capture process is a highly voltage dependent complexation of the two proteins where transmembrane...

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Literature Corpus work: 25835ca6-4c14-5f37-99ec-275d27a0b1c7
DOI: 10.1101/2021.10.15.464579

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