Tuning Rectification and Gating in Biological Nanopores Through Lumen Charge Mutation.

doi:10.1007/978-1-0716-5527-6_3

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Article

Tuning Rectification and Gating in Biological Nanopores Through Lumen Charge Mutation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Mayer Simon Finn, Mitsioni Marianna Fanouria, Marcaida Maria Jose, Emmerich Theo, Radenovic Aleksandra, Dal Peraro Matteo

Abstract excerpt

β-barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to antibiotic resistance in Gram-negative bacteria, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the understanding of the fundamental principles governing ion transport through these nanopores remains in its early stages. In this chapter, we describe...

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PMID: 42663950
DOI: 10.1007/978-1-0716-5527-6_3

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