Article
De novo design of metalloproteases for targeted amyloid-β cleavage
2026-01-06
Abstract excerpt
De novo protein design has not yet achieved the creation of proteases capable of selectively cleaving any desired peptide bond within a native protein with high precision. Here, we report the use of the flow-based generative model Proteus2 to design metalloproteases by generating enzyme–substrate complexes conditioned on a target peptide sequence and a predefined catalytic motif. Our approach employs a two-step en...
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Identifiers and source
- Literature Corpus work
- b979aa5c-c0b8-5d67-b0a2-c85175b8727f
- DOI
- 10.64898/2026.01.06.697903